- Title
- A systematic review and meta-analysis of tumor necrosis factor α-308 polymorphism and Kawasaki disease
- Creator
- Arj-Ong, Sakda; Thakkinstian, Ammarin; McEvoy, Mark; Attia, John
- Relation
- Pediatrics International Vol. 52, Issue 4, p. 527-532
- Publisher Link
- http://dx.doi.org/10.1111/j.1442-200X.2010.03105.x
- Publisher
- Wiley-Blackwell Publishing Asia
- Resource Type
- journal article
- Date
- 2010
- Description
- Background: There have been genetic studies assessing the association between tumor necrosis factor (TNF)-α-308 and Kawasaki disease (KD) but the results have been conflicting due to lack of power. Therefore, a systematic review and meta-analysis was conducted to increase the power for identifying the association between the TNF-α-308 polymorphism and KD. Method: Studies were identified from MEDLINE and EMBASE databases and were included if the subjects were children and the frequencies between TNF-α-308 and KD were reported. Data were pooled using a random effect model if heterogeneity between studies was present. Results: Thirteen studies were identified however only six studies were included. The pooled prevalence of minor A allele was 5.2% (95% confidence interval [CI]: 0.1%–9.5%). Gene effect was assessed using per-allele and per-genotype approaches. The pooled odds ratio of G versus A with the random effect model was 1.13 (95%CI: 0.34–3.27). The genotype effects for GG versus GA+AA was estimated and the pooled odds ratio was 1.08 (95%CI: 0.42–2.92). Conclusion: This review suggests a trend of association between the TNF-α-308 G-allele and KD. However, the gene effects are heterogeneous and assessing sources of heterogeneity are limited. An updated meta-analysis is needed if more studies are published.
- Subject
- genetic association studies; Kawasaki disease; meta analysis; tumor necrosis factor alpha 308
- Identifier
- http://hdl.handle.net/1959.13/921562
- Identifier
- uon:9346
- Identifier
- ISSN:1328-8067
- Language
- eng
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